Research line: Bioethics and Health (Closed)

1. The sexuality of people with blindness

2. Biosafety in health services

3. Research in bioethics: methods and practices.

Closed in 2011:

1.   Ethics and knowledge production: research in human beings?

Research line: Clinical Immunology and Allergy

1. Proteomics analysis for identification and characterization of vaccine candidates against Leishmanial Chagas

2. Evaluation of the upper airways in patients with severe refractory asthma

3. Respiratory allergy and infection by helminths

4. Asthma and allergic rhinitis in Bahia (ProAR)

5. Clinical evaluation of patients carrying hereditary angioedema (AEH) by deficiency of C1-esterase inhibitor

6. Risk factors, endophenotypes and biomarkers of severe asthma

7. Immunogenetics of asthma and schistosomiasis

8. Initiation of Immune Response in Chronic Leishmaniasis

9. Prevalence of wheezing, viral respiratory infection and recurrent wheezing in infants’ development

10. Immunological response, viral factors and helminth infection in the expression of the disease associated with HTLV-1

Closed in 2011:

1. Clinical and laboratory evaluation of patients carrying Primary Immunodeficiency.

2. Evaluation of the ability of antigens of Schistosoma mansoni in modulating the immune response types Th1, Th2 and Th17 in vitro.

3. Evaluation of the impact of PROAR on health resource utilization, cost and mortality from asthma in Salvador.

4. Evaluation of Autologous Serum test and the Autologous Plasma Test in patients with chronic urticaria and autoimmune disease.

5. Assessment of the degree of cell activation and cytokine profile in individuals with varying degrees of hepatic fibrosis secondary to schistosomiasis.

6. Molecular mechanisms involved in modulation of immune response in asthma sufferers infected by Schistosoma mansoni.

Research line: Immunology of Tropical Diseases

1. EVALUATION OF THE IMMUNE RESPONSE OF PATIENTS INFECTED BY Mycobacterium Leprae AND THE CORRELATION WITH THE FUNCTIONAL DISABILITY GRADE

2. Evaluation of the Immune Response and Genetic Markers on Leprosy

3. Evaluation of T NK cells, on schistosomiasis and cutaneous leishmaniasis

4. Functional proteomics evaluation of Lutzomyia longipalpis saliva

5. Characterization of the Immune Response in patients with mucosal leishmaniasis

6. DEVELOPMENT of BIO-INFORMATIC METHODS FOR THE SEARCH IN SILICO CD8 EPITOPES

7. The early stages of human immune response against Leishmania braziliensis: differences in gene expression of high and low responding individuals

8. Clinical and Immunopathological study in patients with Mucosa Leismaniose

9. Study of immunological and environmental factors associated with the resistance to Schistosoma mansoni infection in an endemic area in Bahia, Brazil

10. Integrated study on leishmaniosis

11. IMUNORREGULATION AND INTESTINAL PARASITISM IN CANINE VISCERAL LEISHMANIASIS

12. Identification of genetic markers of the host associated with the pathology and resistance in American Tegumentary Leishmaniasis

13. Impact of derivative components of the vector in innate immune response against the Leishmania: a research project in collaboration with Brazil-Switzerland of a neglected infectious disease
14. Immunopathogenisis of infection by Leishmania braziliensis: role of neutrophils and lymphocytes T CD8 +

15. Molecular Immunopathogenisis of leishmaniasis and HTLV

16. Incidence of cutaneous leishmaniasis in relatives of patients with leishmaniasis and evaluation of the immune response in these individuals.

17. Control mechanisms and Immunoprophylaxis in leishmaniasis.

18. Modulation of the inflammatory response by antigens of Schistosoma mansoni

19. Myeloid lineage and L. brasiliensis

20. The role of lymphocytes T CD4 and CD8 + in initial immune response modulation in biopsies from patients with cutaneous leishmaniasis infected with Leishmania braziliensis

21. Role of Notch Signalling in inflammatory response of leishmaniasis.

22. Role of Th17 cells and regulatory T on Human Mucosa Leishmaniasis.

23. The role of host and parasite in human leishmaniasis

24. Participation of Phagocytic cells in the pathogenesis of cutaneous leishmaniasis

25. Photolysis of chemically sensitized Leishmania is applied to therapy and prophylaxis of cutaneous leishmaniasis

26. Immune response and viral coinfection in disseminated leishmaniasis

27. Protective and pathological immune response in tegumentary leishmaniasis

28. Immune response and tissue damage in infection by Leishmania braziliensis

29. Immune response and co-infection in leprosy.

30. Vaccines blocking transmission of Leishmania chagasi

Closed in 2011:

1. Factors of the host and the parasite in mucosal leishmaniasis.

2. Use of miltefosine in American tegumentary leishmaniasis.

Research line: Infectology

1. Splenic abscess: a secondary analysis of data, clinical and diagnostic criteria

2. Application of the criterion of sepsis in children admitted with fever in an emergency service

3. Association between HTLV-1 and tuberculosis

4. Evaluation of the Brazilian society of Pediatrics recommendation for antibiotic therapy of children with serious or very serious community acquired pneumonia.

5. Evaluation of immune response in individuals infected with HTLV-1 the antigens not related to the virus

6. Bacteraemia in Paediatric age group

7. Bacteraemia related to a double-lumen catheter for haemodialysis in a SUS hospital in Bahia: Staphylococcus aureus and its susceptibility profile

8. Genetic and environmental determinants of Symptomatic and asymptomatic Leishmaniasis.

9. Molecular Epidemiology of Hepatitis Virus in Brazil

10. Study of the aetiology of community-acquired pneumonia by specific and non-invasive methods in hospitalized Brazilian children

11. Study of the effectiveness of amoxicillin administered in two or three daily doses in children with community-acquired pneumonia with non-serious presentation

12. Study of therapeutic failure of oxacillin or cephalotin in children with uncomplicated cellulitis.

Closed in 2012:

13. Studies on the Mechanisms of Gene Expression and the Epigenetic Regulation in American Tegumentary Leishmaniasis in a population of Bahia, Brazil

14. Risk factors for cerebrovascular disease and prognosis of Chagas disease

15. Frequency of strains of Methicillin-resistant Staphylococcus aureus in a public hospital in Salvador, Bahia
16. Hepatotoxicity of paracetamol in patients with dengue

17. INCT of Tropical Diseases – subproject Leishmaniasis.

18. INCT of Tropical Diseases – subproject Neurology

19. CLINICAL-EPIDEMIOLOGICAL INDICATORS OF SEVERITY IN ACCIDENTAL TETANUS: A HISTORICAL SERIES

20. Incidence of community-acquired pneumonia with emphasis for pneumococcal etiology in children under 5 years in Salvador, Northeast Brazil.

21. Visceral leishmaniasis in the elderly

22. Communicable diseases in Rondônia

23. Epidemiological profile of hospital-acquired infections in a paediatric hospital in Salvador, Bahia, between 2002 and 2005

24. Specific prevalence of different respiratory viruses in infants with acute respiratory infection

25. The role of Leishmania braziliensis strain polymorphism on disease outcome and distribution

26. Urbanization of endemic diseases in the city of Salvador, Bahia: paradoxes of development and the challenges for public health

27. Validation test in-house for HBV/HCV and VHD viral loads

Closed in 2011:

1. Study of the characteristics of St Louis encephalitis.

2. INFLUENCE of ECOLOGICAL CHANGES IN THE PRODUCTION CIRCUIT OF LEISHMANIOSES IN AN AREA IN THE STATE of BAHIA.

3. Second pre-core mutation viral genotypes in dry and wet tropics of Brazil. PROSUL in cooperation with Argentina.

Research Line: Clinical Research

1. Clinical and epidemiological aspects of HCV/HTLV-I coinfection

2. Association between obesity, immune response and severity of psoriasis

3. Assessment of the effectiveness of Pentoxifylline in the treatment of myelopathy associated with HTLV-1

4. Evaluation of the relationship between iron overload and biochemical markers in patients with HCV infection as predictive factors of evolution of liver fibrosis

5. Thyroid evaluation in the course of Hepatitis C treatment with Interferon alfa: morphology, function and expression of Autoimmunity

6. Evaluation of the therapeutic potential of diethyldithiocarbamato (DETC) in cutaneous leishmaniasis using synthetic carriers

7. Determination of frequency of headaches post lumbar puncture

8. Parkinson’s disease

9. Integrated studies in leishmaniosis. Evaluation of therapeutic effectiveness of the association of antimony + Pentoxifylline in cutaneous leishmaniasis

10. Effects of revaccination with BCG in the clinical and immunological profiles related to atopy

11. Intracranial arterial stenosis

12. Prospective study on glomerulopathy in Bahia (PRO-GLOM)

13. Frequency of vaccination delay and feeding error in children admitted in an emergency service

14. Genetics in cerebrovascular diseases

15. Identification of biomarkers associated with the severity of Psoriasis Vulgaris

16. Impact of nasal-sinusal endoscopic surgery in the treatment of patients with antrochoanal polyps

17. The implementation of good laboratory practice management - BPL in a research laboratory in the Centro de Pesquisa Gonçalo Moniz-FIOCRUZ/BA.

Closed in 2012:

18. Influence of atopy in the neurological manifestations caused by the HTLV-1

19. Dermatological manifestations in individuals infected with HTLV-1 in Salvador, Bahia

20. BIOLOGICAL MARKER TO DISTINGUISH BETWEEN DIFFERENT VIRAL AND BACTERIAL ETIOLOGIC AGENTS IN CHILDREN WITH COMMUNITY-ACQUIRED PNEUMONIA

21. Neurointensivismo

22. Predictors of dialysis and mortality in patients with acute renal failure in intensive care

23. Prevalence of HTLV-1 in haemodialysis.

24. Quality of life after in relation to health after a stroke in adults participating in a rehabilitation program.

25. Rehabilitation in cerebrovascular diseases

26. Immune response associated with clinical and therapeutic developments in patients in the pre-ulcerative stage of cutaneous leishmaniasis

27. HASHIMOTO'S THYROIDITIS ASSOCIATED with PAPILLARY THYROID CARCINOMA

28. Diagnostic value of the classic signs of meningeal irritation

Closed in 2011:

1. Distribution of hepatitis C virus genotypes in accordance with the presence of thyroid autoantibodies in the course of treatment with IF-alpha.

2. Neglected diseases.

3. Visceral Leishmaniasis – new prophylactic and therapeutic approaches in canine visceral leishmaniasis.

4. Acute renal injury in the intensive care unit.